A study of antihypertensive anti inflammatory and lipid lowering effects of terminalia arjuna in spontaneously hypertensive rats

Abstract

newline Now a day s hypertension is the most exigent problem due to its frequent developing tendency and high impact on the development of cardiovascular dysfunction which is adversely affecting public health. Management of hypertension generally focuses on reducing high blood pressure and modulation of lipid profile to reduce overall cardiovascular risk. Apart from available antihypertensive management, various herbs which contain strong medicinal properties are also used as an effective way to reduce the high blood pressure. Concomitant supplementation of the herbal extracts, diet intervention prevents cardiovascular complications and may be helpful in management of hypertension adjuvant with available anti-hypertensive drugs. newlineNumerous studies have showed that several angiosperms including Terminalia arjuna, Myrobalan, Terminalia elliptica, Terminalia bellirica have potential medicinal properties. In ancient history of Indian ayurveda, Terminalia arjuna is widely used as powerful medicinal plant for alleviating angina called hritshool and other cardiovascular disorders. Its bark has many biochemical constituents which has significant effect on blood pressure, improves coronary flow and protects against ischemic damage. Terminalia arjuna(TA) is a versatile type of land plant with many medicinal properties which includes large amount of bioactive constituent and phytochemicals such as phytosterols, triterpenoids, saponins, alkaloids, carbohydrates, flavonoids, phenolic compounds, tannins, proteins, and glycosides. newlineSeveral studies have elucidated effects of TA on various major disorders including congestive heart failure, liver diseases, and hyperglycemia, but there are very few reports regarding Aqueous effect of TA on various cardiovascular parameters and serum lipid levels in different doses in spontaneously hypertensive. So in present study, we evaluated the effect of TA on Blood pressure, coronary flow, inotropy, chronotropy and lipid profile in Spontaneously Hypertensive Rats (SHR). newlineThe present stu