Development and screening of hybrid streptokinases towards clotspecific activity

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dc.contributor.guideMurugan Ven_US
dc.coverage.spatialDevelopment and screening of hybrid streptokinases towards clotspecific activityen_US
dc.creator.researcherHarith kamil boneyaen_US
dc.date.accessioned2015-02-10T09:53:40Z
dc.date.available2015-02-10T09:53:40Z
dc.date.awarded30/09/2009en_US
dc.date.completed01/09/2009en_US
dc.date.issued2015-02-10
dc.date.registeredn.d.en_US
dc.description.abstractStreptokinase is a bacterial origin protein and is used as an newlineeffective and cheap clotdissolving medication in myocardial infarction heart newlineattack stroke pulmonary embolism and deep vein thrombosis It is a single newlinechain polypeptide made up 414 amino acid residues and has molar mass of newline47kDa SK is probably one of the vital affordable therapies especially in the newlineworlds poorer health because its markedly lower cost when compared to newlinetPA and Urokinase SK by it self is not plasminogen activator but bind with newlinefree circulating plasminogen to form 11 stochiometric complex that can newlineconvert additional free plasminogen to plasmin Its immunogenicity short newlinehalf life in circulation and its lack of clot specificity limits its therapeutic potential newline newlineen_US
dc.description.noteReference p.188-195en_US
dc.format.accompanyingmaterialNoneen_US
dc.format.dimensions23cmen_US
dc.format.extentxv, 197p.en_US
dc.identifier.urihttp://hdl.handle.net/10603/34246
dc.languageEnglishen_US
dc.publisher.institutionFaculty of Science and Humanitiesen_US
dc.publisher.placeChennaien_US
dc.publisher.universityAnna Universityen_US
dc.relationp.188-195en_US
dc.rightsuniversityen_US
dc.source.universityUniversityen_US
dc.subject.keywordclotspecific activityen_US
dc.subject.keywordhybrid streptokinasesen_US
dc.subject.keywordscience and humanitiesen_US
dc.titleDevelopment and screening of hybrid streptokinases towards clotspecific activityen_US
dc.title.alternativeen_US
dc.type.degreePh.D.en_US

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