Development and screening of hybrid streptokinases towards clotspecific activity

Abstract

Streptokinase is a bacterial origin protein and is used as an newlineeffective and cheap clotdissolving medication in myocardial infarction heart newlineattack stroke pulmonary embolism and deep vein thrombosis It is a single newlinechain polypeptide made up 414 amino acid residues and has molar mass of newline47kDa SK is probably one of the vital affordable therapies especially in the newlineworlds poorer health because its markedly lower cost when compared to newlinetPA and Urokinase SK by it self is not plasminogen activator but bind with newlinefree circulating plasminogen to form 11 stochiometric complex that can newlineconvert additional free plasminogen to plasmin Its immunogenicity short newlinehalf life in circulation and its lack of clot specificity limits its therapeutic potential newline newline