Design of novel molecular libraries as inhibitors of and#945; Glucosidase Potent hybrid compounds against type ii Diabetes

Abstract

This thesis mainly consist of five chapters describing the evaluation of potent and#61537;-glucosidase newlineinhibitor for treatment of diabetes. First chapter introduces diabetes and it s therapeutic approaches newlineand also it describes various existing potent inhibitors. Second chapter involves design, synthesis, newlinein vitro and in vivo studies of a novel library of and#61537;-arylketones as potential inhibitors of and#61537;- newlineglucosidase. Chapter three includes detailed study of design, synthesis and in vitro study of densely newlinefunctionalized oxindoles as potent and#61537;-glucosidase inhibitors. Fourth and fifth chapter describes the newlinedesign and synthesis of novel pyridone based and#61537;-glucosidase inhibitors along with their biological newlineevaluation, in vitro ADME-Tox and in vivo pharmacokinetics studies. newline