Evaluation of hepatoprotective and antioxidant activity of Lagerstroemia speciosa extract against Isoniazid and Dapsone induced hepatotoxicity in Wistar rats

Abstract

Excessive alcohol consumption, HBV and HCV infections, aflatoxin newlinecontaminated food, and non-alcoholic steatohepatitis are considered as important newlineetiological factors for the progression of CLD. According to WHO, India is newlineresponsible for 2.95% of total liver disease-related deaths, where HBV infection newlineand alcohol intake remained the most common cause of CLD, and primary runner newlinefor cirrhosis/HCC. Therefore, in this study, we investigated the cytotoxic, pro-apoptotic and cell cycle arresting potential of EBLE against newlinehepatocellular cancer cell line i.e. HepG2 cells newlineDILI is one of the most serious problem worldwide and it is a cause of newlineconcern. According to Devarbhavi et al. (2010), anti-tubercular drugs and dapsone newlinetogether responsible for 63% of DILI in the Indian patients. Hence, DILI poses a newlinechallenging clinical problem with respect to both diagnosis and management newline(Ezhilarasan, 2019). Despite significant advancement in diagnosis, hazard newlineidentification and risk mitigation, DILI continues to be a difficult task for drug newlinedevelopment and a major health concern worldwide (Mosedale and Watkins, newline2017). Therefore, in this study, we investigated the antioxidant and newlinehepatoprotective effect of EBLE against DDS alone, INH alone and DDS+INHinduced newlinehepatotoxicity in rats. newlineThe aim, objectives, hypothesis and ethical consideration are embodied in newlinethe forthcoming chapter of this thesis newline