Synthesis of amino organoselenium compounds and evaluation of antioxidant activities

Synthesis of amino organoselenium compounds and evaluation of antioxidant activities

dc.contributor.guide	Singh, Vijay Pal
dc.coverage.spatial	Inorganic Chemistry
dc.creator.researcher	Nikhil
dc.date.accessioned	2025-09-29T08:22:56Z
dc.date.available	2025-09-29T08:22:56Z
dc.date.awarded	2026
dc.date.completed	2025
dc.date.registered	2019
dc.description.abstract	The present thesis focuses on the synthesis and evaluation of aminic and benzylamine-based organoselenium compounds, along with 1,3-benzoselenazoles. It provides an overview of oxidative stress-related diseases, ferroptosis, lipid peroxidation, radical-trapping antioxidants, selenium s antioxidant role, GPx-mimetic behaviour, and computational methods (DFT, docking, MD). Synthesized compounds were structurally characterized (including X-ray crystallography) and exhibited strong GPx-like activity, anti-ferroptotic effects, antibacterial activity against E. coli and S. aureus, and promising anticancer potential supported by molecular docking studies. newline
dc.description.note	Bibliography 141-184p.
dc.format.accompanyingmaterial	CD
dc.format.dimensions	-
dc.format.extent	xix, 184p.
dc.identifier.researcherid	0000-0002-9611-1375
dc.identifier.uri	http://hdl.handle.net/10603/665156
dc.language	English
dc.publisher.institution	Department of Chemistry
dc.publisher.place	Chandigarh
dc.publisher.university	Panjab University
dc.relation	-
dc.rights	university
dc.source.university	University
dc.subject.keyword	Benzoselenazoles
dc.subject.keyword	Ferroptosis
dc.subject.keyword	GPx enzymes
dc.subject.keyword	Organoselenium
dc.subject.keyword	Radical Trapping Antioxidant
dc.title	Synthesis of amino organoselenium compounds and evaluation of antioxidant activities
dc.title.alternative
dc.type.degree	Ph.D.