Study on the effect on silica nanoparticles on Rat Central Nervous System Protective effect of Docosahexaenoic acid

Abstract

newline In the recent years, much consideration has been aimed at the potential of newlinesilica toxicity, which is found within the earth s crust in the form of crystals made newlinefrom various components, viz. sand, soil and other natural materials. The form of newlinesilica nanoparticles is more robust in the field of human toxicity. Silica nanoparticles newline(SiNPs) are found in nature 100 times smaller than natural sand particles. Due to newlinetheir small size, these kinds of particles can easily pierce the human respiratory newlinesystem and circulate through the blood and it may be deposited in various tissues newlineand organs. Silica in the body caused kind of deterioration and biochemical changes newlinewhich leads to cause severe diseases. In addition, Nervous system is the most newlinevulnerable organ of the silica toxicity which may cause reduced efficiency of the newlinebrain. It is well documented that SiNPs induced neurotoxicity may lead to change newlinecognitive efficacy. The mechanism of SiNPs neurotoxicity is not well documented. newlineIn the present study, we hypothesized that the generation of reacting oxygen species newlineand reduced antioxidant status may be one of the prospective mechanisms for the newlineneuronal toxicity induced by SiNPs. In the present study, we aim to evaluate the newlinedose dependent effect of silica on different brain regions and protective potential of newlineDocosahexaenoic acid (DHA) was tested in male albino rats. Various biochemical newlineand behavioural test were carried out in the male albino rats.