Pharmacognostic and Pharmacological Evaluation of Medicinal Plant Formulations for Anti Thyroid Activity

Abstract

Imbalance of thyroid hormone T3 and T4 associated with which is secreted by the thyroid gland directly into the blood. The severity of imbalance of these hormone leads to common diseases like diabetes, hypertension, disturbance of BMR of the body. Approximately half of the cases of thyroid disease involve Hypothyroidism and half of Hyperthyroidism. Even though day-by-day herbal drugs are gaining much importance for their affordable and safe nature, scientific investigations towards the mitigation of thyroid disorders by the plant extracts are merger. In the present study the selected medicinal plants are rich in rosmarinic acid RA and, it can cure the hyperthyroidism by, affecting of TSH on receptor site, also inhibit immunoglobin effects on Thyroid stimulating hormone (TSH) receptor, and it also decrease the peripheral conversion of T3. The rosmarinic acid may also beneficial in the treatment of Grave s diseases. The selected dosage form is convenient and can effectively treat the hyperthyroidism newlineThe aim of present study is to isolation of rosmarinic acid from selected medicinal plants material, optimization of dose of RA for hyperthyroidism, formulation and development sustain release of tablet dosage form of optimized dose of RA, In-vitro and In-vivo evaluation for hyperthyroidism. newlineObjective newlineFormulation, development and Evaluation of RA sustain release tablet dosage form for antithyroid activity. newlineMethod newlineTwo medicinal plants fruits Helicteres isora linn (HI) fruits and Psidium guajava liin (PG) were selected for study, plant material ware authenticated from BSI Pune, authenticated material standardized and then proceeded for macroscopic and microscopic evaluation. Then plant material ware subjected for extraction and phytochemical screening. TLC and HPTLC analysis ware carried out for phytochemical investigation and HR-LCMS analysis of extracts for the confirmation that selected medicinal plant material rich in RA. newlineIsolation of RA from selected medicinal plant material was carried out by using column chromatogr