Effect of ethanolic extract of Asparagus racemosus root and its active component steroidal saponin in fructose and letrozole induced polycystic ovary syndrome in Wistar rats

Abstract

Perpetuation of one s race is the dogma of all living organisms. All newlineliving organisms strive to achieve this through the process of reproduction, newlinewhich is the vital process that enables a species to represent itself in the newlinefollowing generations in the form of its offsprings. Different contraceptive newlinemethods are in practice for family planning (population control) but at the newlinesame time there are married couples who are facing the problems of infertility. newlineStatistics reveals that infertility is one of the most alarming associated newlinemorbidities, which affects approximately 48.5 million women aged 20 44 newlineyears. PCOS accounts for 6 15% of these cases, although up to 70% of newlinewomen with PCOS may be undiagnosed (Boyle et al, 2012). newlinePCOS is associated with multiple hormonal imbalances dominated by newlinehyperandrogenism. The scope of management of PCOS is also very less and newlinethe treatment available sometimes is not yielding satisfactory results. Despite newlinegreat advances in modern medicine in recent decades, herbal plants still newlinemake an important contribution to healthcare. Numerous plants have been newlineused traditionally to treat PCOS and modern scientific research has confirmed newlinethe fertility effects in some of the herbs, but still needs documentation of the newlineresearch. This study was done to document the beneficial effect of AR on PCOS, which has been used traditionally in Indian system of medicine since newlineages. Also, the efficacy of steroidal saponin on PCOS component of AR is not newlinestudied and documented so far in available open access literature and newlinejournals. The present research work was taken to prove the effect of AR newlineextract and its component steroidal saponin on female Wistar rats. newline