Study on fabrication of silk fibroin paramylon based biomimetic and instructive materials for chronic wound healing

Abstract

Chronic wounds are one among the dangerous issues that are predicted to affect 2 6 crore people around the world by 2026 due to the endless rising of obesity aging diabetes and change in lifestyle These wounds are more than just a cost burden as they create immobility and worthlessness of life due to the disability to perform daily tasks Factors responsible for the chronicity in wounds are continuous trauma debilitating illness increased bacterial protein ischemia excessive proteases destruction of extracellular matrix ECM and growth factors that are mandatory for healing Thus to positively regulate the proteases like Matrix metalloproteases and to activate the growth factors and ECM Biomimetics is one of the favourable approaches to develop an ECM like dressing to progress the wound healing process in chronic wounds Due to the increasing interest and the ECM framework Protein Polysaccharide complex driven the curiosity in developing a biomimetic and instructive wound dressing using silk fibroin protein and Paramylon polysaccharide based complex of different forms have been studied to develop a self care wound dressing for chronic wounds Primarily to study the suitability silk fibroin and paramylon blended films was prepared in different ratio 100 0 75 25 50 50 75 25 and 0100 Later three forms of Silk fibroin and paramylon based materials was fabricated such as 1 Silk Fibroin based non woven mat functionalized with 0 25 0 5 and 1 paramylon 2 Alum loaded FG 75 25 coated cellulose sponge for exudate wounds and 3 Paramylon coated silk fibroin sponge sheet newline newline