Chemicobiological interactions of caffeoyl derivatives from cichorium intybus with protein tyrosine phosphatase 1b ptp1b an in vitro in silico and in vivo approach

Abstract

Diabetes mellitus is a chronic metabolic syndrome characterised by newlineimpaired metabolism of glucose resulting from defects in insulin secretion newlineinsulin action or both The World Health Organization WHO estimates that newlineapproximately 135 million people worldwide currently have diabetes and in newlinethat type 2 diabetes accounts for around 90 The decline in the ability of newlinemuscle fat and liver cells to respond to insulins actions is known as Insulin newlineResistance The loss of insulin action selectively in adipose tissue leads to newlinesecondary disorders like obesity and atherosclerosis by malfunctioning newlineadipogenesis Additionally the progression of diabetes and associated newlinecomplications has also been observed to increase with obesity newline newline