Blue LED induced reactions of diazoesters and diazonium salts: Their application in the formation of new C–X (X = C, O, N) bonds

Abstract

Over the last decade, visible-light-driven organic reactions have seen a remarkable resurgence, driven by the growing demand for environmentally friendly green chemical synthesis. These organic transformations, harnessing inexpensive and easily accessible visible-light systems, have emerged as a robust approach for activating small molecules. The exclusive use of visible light as the energy source in such processes is particularly compelling. newline newlineDiazo compounds hold a prominent position in synthetic organic chemistry both in terms of their synthesis and reactivity, having been extensively studied since the late 19th century. Notably, photochemical reactions of diazo compounds, which serve as crucial precursors for free carbene formation, have emerged as a valuable alternative to transition metal catalysis. These reactions rely solely on visible light as the energy source, aligning with the principles of green chemistry. newlineIn this direction, my thesis will be structured as follows, newlineIn the first chapter of my thesis, we will review the latest developments in the visible-light-driven transformations of diazo compounds, which enable access to intermediates such as carbenes, radicals, and others, that are often difficult to access by other methods. newlineIn the second chapter, we will discuss the blue LED mediated in situ generation of pyridinium ylides from aryl diazoesters and their applications in synthesizing diverse dihydroindolizine derivatives. newlineIn continuation of our previous endeavour, the third chapter demonstrates an efficient one-pot synthesis of aromatic and#945;-ketoamides using blue LED in oxygen from aryl/heteroaryl acetates and cyclic 2 amines. newlineFurthermore, the site selective functionalization of a wide range of 1,4-quinones with various electronically different diazo acetates under visible light, in the absence of base/acid/catalyst, will be discussed in the fourth chapter of my thesis. newlineFinally, in the fifth chapter, we have unveiled a blue LED induced, oxone promoted cascade reaction se