Design and development of immobilized, recyclable catalysts for C-C, C-N, S-N bond formation and selective hydrogenation reactions

Abstract

The thesis deals with the design, development and application of immobilized catalysts for various C-C, C-N, S-N bond formation reaction and selective hydrogenation reactions. Immobilized catalysts are particularly attractive for the synthesis of fine chemicals as they allow the production and ready separation of large quantities of products with the use of a small amount of catalyst. Further, in the recent years, the stringent environmental legislations and increasing awareness for human health have put more emphasis on cleaner and greener technologies which helps in reducing the amounts of toxic wastes and effluents. Immobilized and recyclable catalysts are immensely helpful in this context. The thesis is divided into five chapters. Chapter I highlights the importance of cleaner catalytic technologies for the synthesis of fine chemicals and pharmaceuticals. Further, this chapter focuses on the properties and applications of inorganic solid supports, ionic liquids and soluble polymers for various organic transformations. Chapter II deals with the preparation and application of nanocrystalline magnesium oxide supported palladium(0) for C-C bond formation reactions and reduction of nitro compounds and alkenes using molecular hydrogen as a reducing agent. Chapter III describes in detail, the synthesis, characterization and application of magnesium oxide supported on mesoporous carbon for the synthesis of sulfinamides. Chapter IV deals with the synthesis and application of mesoporous aluminosilicates and ionic liquids in the ring opening of epoxides with amines and nitrogen heterocycles. Chapter V details the synthesis, characterization and application of Poly (N-vinyl-2-pyrrolidone)-Cu(OAc)2 in the sulfimidation reaction using PhI=NTs [(N-(p-tolylsulfonyl)imino]phenyliodinane) as newlinenitrene donor.