Surface Functionalized Biocompatible lipid Nanocarriers as an Oral Anti Leishmanial Therapy

Abstract

Oral therapy is often one of the most preferred routes of drug administration on account of its newlinelow cost, ease of use, and superior patient compliance. Traditionally, oral therapy has been newlinethe most popular and dominant controlled drug release, yet it was ascertained that more than newline90% of therapeutically active compounds possess bioavailability constraints when newlineadministered orally. However, the hostile enzymatic environment of the gastrointestinal tract newline(GIT) poses a massive challenge for orally administered bioactives. Thusly, the development newlineof enzymatically stable nanocarriers is the immediate priority to enhance the newlinepharmacokinetics and biodistribution kinetics. Additionally, conventional drug therapy is newlineusually characterized by diminutive half-lives and pervasive delivery to non-targeted cells. newlineTo mitigate stability issues and drug-associated toxicity, nanotechnology-based drug delivery newlineplatforms have entered the targeted therapy arena and rapidly sculpt complex formulations. newlineThe advent of nanotechnology has emerged as a powerful ally owing to its size-dependent newlineunique physio-chemical properties. The remarkable potential of nanocarriers has attracted newlinetremendous applications in enhancing the bioavailability and pharmacokinetic profile of the newlineincorporated drug. Additionally, surface functionalization of the nanoparticle drug delivery newlinesystem has been proposed to enhance their performance in complex biological systems and newlinelocalize the therapeutic moiety to the desired site of action. Specific biocompatible molecules newlinecan be immobilized onto the surface of these nanocarriers to generate membrane-mimetic newlineplatforms for drug delivery applications. Among the various drug delivery systems, lipid- newlinebased nanocarriers have emerged as one of the most promising versatile vehicles to deliver newlinetherapeutic agents effectively. These colloidal drug delivery systems composed of newlinephysiologically derived lipids offer ubiquitous advantages of enhanced permeation and higher newlinedrug loading of hydrophilic and hydrophobic drugs. Concurrently