Stability and cytotoxicity studies on gold nanoparticles and medical applications

Abstract

Nanotechnology is defined as the understanding manipulating and newlinecontrolling things at nanoscale where the unique properties of materials newlinearises that enable novel applications Gold is considered to be noble among all newlinemetals due to its resistance to surface oxidation because of this it is known as newlinethe king of the metals Contrary to the nobility of bulk gold exciting newlineproperties can be attributed to gold at the nanoscale Nowadays gold newlinenanoparticles AuNps are used by a large number of scientific communities newlineas a perfect material for the scientific studies The research involves the newlineanalysis of optical properties of metal nanoparticles and the mechanisms newlineinvolved in the aggregation stabilization and its potential applications in newlinedifferent fields of medicine engineering and material research Gold newlinenanoparticles also possess a strong surface to volume ratio which renders newlinethem suitable for attachment with biomolecules It can be used for clinical newlinedevelopments in cell labeling providing contrast in biological imaging drug newlinedesign and time bound delivery at the specific location of the disease by newlineconjugating gold nanoparticles with proteins or biomolecules that impart high newlineaffinity to target and at various disease pathologies newlineIn the present research work gold nanoparticles stabilized with newlinecitrate starch and gum arabic have been synthesized and characterized The newlineAuNps were studied for their in vitro stability and cytotoxicitiy studies The newlinestability of the gold nanoparticles over a period of time of 240 hr at room newlinetemperature the addition of different concentration of electrolyte and the newlinechange of pH were monitored using absorption spectroscopy and Zeta newlinepotentiometer The AuNps were further stabilized with polyethylene glycol newlineand then used for medical applications newlineConflicting reports on gold nanoparticles as toxic and nontoxic newlinehave therefore been dedicated in the elucidation of toxicity of gold newlinenanoparticles in this work newline newline newline newline