Comparison of effectiveness of hyaluronic acid and melatonin with GTR versus GTR alone in treatment of intrabony defects in human subjects a split mouth randomized controlled trial

Abstract

Background newlineSeveral regenerative materials have been attempted and evaluated for the regeneration newlineof intrabony defects in patients with chronic periodontitis. Melatonin is one such substance newlinethat is primarily generated by the pineal gland and numerous other tissues and has vital newlineinvolvement in many physiological processes, including bone remodelling. Over the last newlineseveral years, another emerging molecule serving as a potential candidate for periodontal newlineregeneration is the hyaluronic acid (HA), a key extracellular matrix component involved in newlinecell migration. newlineAim newlineTo evaluate the additive effect of hyaluronic acid and melatonin with GTR membrane in newlineintrabony defects among patients with chronic periodontitis. newlineMaterials and Methods newlineIn this randomized controlled clinical trial, 15 bilateral intra-bony defects were treated newlineeither with Hyaluronic acid and melatonin along with GTR membrane (Group I), or GTR newlinemembrane alone (Group II). Clinical and radiographic parameters assessed were pocket newlinedepth, clinical attachment level, and volume of bone defect at baseline and 6 months after newlinethe intervention. The biochemical parameter assessed was Matrix metalloproteinase - 1 newline(MMP-1) and Tissue inhibitor of metalloproteinase (TIMP-1) at baseline and one month newlineafter the intervention. newlineResults newlineBoth the study groups showed statistically significant differences in all the parameters newlinefrom baseline to follow-up. However, group 1 (Hyaluronic acid + Melatonin + GTR newlinemembrane) showed statistically significant improvement in all the study parameters when newlinecompared to group 2 (GTR alone). newlineConclusion newlineWithin the limitations of this study, it can be concluded that the combination of newlinehyaluronic acid and melatonin was effective in the regeneration of intrabony defects among newlinepatients with chronic periodontitis. However, further studies with a longer time period and newlinewith additional microbiological assessment would be desirable so as to substantiate the newlinecurrent results. newline