DEVELOPMENT AND EVALUATION OF SOME NOVEL NANOSUSPENSION

Abstract

In the present study the formulation of nanosuspension was prepared by Quassi emulsification solvent diffusion method .With a aim to improve water solubility of the poorly water soluble drug such as Zaltoprofen, Lornoxicam,Ketoprofen,,Meloxicam belong to the BCS Class-II, the total eight formulation of each drug was prepared with varying proportion of polymer such as Eudragit RS100/Eudragit RL100 along with the stabilizer poloxamber 407.The formulated all nanosuspension were evaluate for the Particle size analysis, Saturation Solubility , drug entrapment , invitro dissolution studies, Zeta potential, short term stability studies and the result show the stable nanosuspension with nanosize drug reduction with polymer Eudragit RS100 with proper coat on drug with maximum drug entrap compare to Eudragit RL00. Saturation solubility of such nanosuspension reveals that the aqueous solubility of drug is significantly increased due to decrease in particle size(80-300 nm). The short term stability studies was performed at two set of temperature 4 oC and 37 oC prove that the drug in nanosuspension can be remain stable at temperature 4 oC .Zeta potential was found to be optimum which show the formulation are stable. Invitro drug release from the nanosuspension show sustained /diffusion release of drug from the polymeric nanosuspension. newline From the above studies it is concluded that the poloxamber 407 stabilizer (Pluronic 127) can be used for formulating stable nanosuspension with varying concentration in range of 0.5-1.0 %. It gives effective size as well as stability to nanosuspension. The ratio of Drug, polymer and stabilizer (Drug, Eudragit RS100 and Poloxamber 407) is important to obtain the stable nanosuspension. The ratios which were selected for preparation of nanosuspension i.e. 1:2:0.5 and 1:2:1.Eudragit RS100 is more effective polymer in the formulation of nanosuspensions than Eudragit RL100. newline