Design synthesis and evaluation of peptide conjugates for alzheimer 8217 s amyloid disruption

Abstract

The cleavage of the backbone of a peptide or protein related disease may treat the disease to heal We noted that supramolecular interactions govern all of the protein aggregation Therefore we hypothesized that a novel way of intervention may be outlined by combining the supramolecular interactions and chemical reactions So we engineered a small peptide to cleave the disease prone Amyloid b Ab selectively and its toxic oligomers at the enzymatic cleavage sites especially that of a secretas...