Computationalinvestigation of hiv 1 protease dynamics by comparing the effects of mutation force fields and pressure

Abstract

AIDS one of the major epidemics of the human society has been the constant worry UNAIDS projection shows the existence of millions of AIDS patients at the end of 2008 with high mortality rate and fresh infections in coming days All the FDA approved drugs are getting resistant against the clever HIV because of its frequent mutations Hence there is an urgent need of developing new drugs with greater potential AIDS is mainly due to the infection of retrovirus HIV It infects the CD4 cells of