Mechanisms Involved in the Emergence of Antibiotic Resistance among Pseudomonas aeruginosa and Strategies to Predict and Prevent Nosocomial Infections

Abstract

Pseudomonas aeruginosa is a leading cause of Hospital Acquired Infections (HAI) and is newlineresponsible for approximately 10% of all HAI worldwide. It continues to pose a greater newlinetherapeutic challenge due to high rate of morbidity and mortality associated with it and the newlinepossibility of development of drug resistance during therapy. Increasing utilization of medical newlineimplants or devices is considered to be a major contributing factor for these infections. Treating newlineresistant P. aeruginosa infections in a critically ill hospitalized patient poses significant newlinechallenges.Hence it becomes important to gain more insights into the various mechanisms newlineadopted by this deadly pathogen to develop antibiotic resistance. newline