A Study on Micellization Behaviour of Pharmaceutical Drugs in Aqueous Electrolytic Solutions

Abstract

Surface science is a fascinating scientific subject that defines the issue of amphiphiles and more specifically micellar and thermodynamic characteristics of surface active substances called surfactants. The surfactants have wide spread applications in the field of drug delivery, detergency, pharmaceutical formulations and solubilization of drugs. Out of these applications, applications in the field of drugs are of paramount importance in the present scenario of struggle for existence of human beings. newlineIn this context, the pharmaceutical drugs can be classified in two different categories i.e. surface active drugs and surface inactive drugs and majority of these pharmaceutical drugs are surface active. Surface active drugs because of their surfactant like nature assemble to form small organized aggregates such as micelles, micro-emulsion and vesicles, used as models to stimulate life system at a concentration known as critical micelle concentration (CMC). Micelles provide important functional properties to drugs which in turn change in the presence of additives (electrolytes and non-electrolytes). Addition of electrolytes in drug solution is another way of reducing CMC of drug. In the presence of salt, the repulsive forces of head groups of drug monomer decreases due to the electrostatic shielding effect resulting in the formation of micelle at lower CMC. newlineTwo amphiphilic drugs viz. streptomycin sulphate ( first-line antibiotic which is used against gram negative bacteria) used in the treatment of tuberculosis, mycobacterium avium complex, endocarditis, burkholderia infection, plague, tularemia, and rat bite fever and diphenhydramine (DPH) a first generation anti-histaminic (H1-receptor antagonist) possessing anti allergic, antitussive, antiemetic and sedative properties that is mainly used to treat allergies have been studied. newlineThere is no previous study reported about analysis of streptomycin and diphenhydramine in the presence of electrolyte system with the help of conductometric, viscometric