Synthesis Structural Elucidation and Pharmacological studies of Metal Complexes with Biosensitive Ligands

Abstract

The area of inorganic chemistry, which most widely developed in the last few decades is mainly due to coordination chemistry and applies very particularly to the coordination compounds of transition metals. The chemistry of coordination compounds has always been a challenge to the inorganic chemists. Metal ion dependent processes are found throughout the life science and vary tremendously in their function and complexity. In literature, several reports linked the significance of biological activity of metal complexes with the metal ions rather than with the ligands. Transition metals are involved in numerous biological processes. The identification of metal complex Deoxyribonucleic Acid (DNA) interaction is of fundamental importance to the understanding of the molecular basis of therapeutic activity. newlineThis field of modern chemistry uses Schiff bases and their transition metal complexes for a variety of applications. Schiff bases have been often used as chelating ligands in coordination chemistry, in catalysis, anti-oxidative activity, anti-bacterial activity, medicine as antibiotics, anti-inflammatory agents, in industry for anti-corrosion properties. On the industrial scale, they have wide range of applications such as dyes and pigments. The Schiff base metal complexes are also very useful model systems in chelate chemistry. The metal ion in such complexes can be coordinated by the imine nitrogen atom and also by the other active centres present in the molecule. This can lead to many interesting catalytic and potential properties. In recent decades, metallo complexes have received much attention in chemistry, biochemistry, and pharmacy as promising compounds for the creation of novel drugs. On the one hand, using such complexes, it is possible to avoid some negative effects inherent in drug compositions containing inorganic salts, which can dissociate with the formation of metal ions. On the other hand, metal ions can modify both magnitude and direction of the pharmacological activity of the initial organic compo