Synthesis Characterization and Biological Studies of Metal Complexes Derived From Quinoxaline Derivatives

Abstract

ABSTRACT newlineMost drugs are organic or biologically derived compounds, and the pharmaceutical newlineindustry focuses on organic chemistry with some exceptions. Metal-based newlinetherapeutics comprises only a small percentage of available drugs. After the newlinediscovery and successful clinical applications of the Pt-based anticancer drug newlinecisplatin, however, research on metal-based drugs became increasingly more newlineimportant. There is a growing interest in metal-containing drugs, and medicinal newlineinorganic chemistry covering applications of metals in therapeutics and diagnostics is newlinea field of increasing prominence. The major advantage of metal-based over organicbased newlinedrugs is the ability to vary coordination number, geometry, and redox states. newlineCisplatin is one of the most widely used anticancer drugs, administered particularly newlinefor ovarian and testicular cancer. Due to the significant side-effects include nausea, newlinebone-marrow suppression, and nephrotoxicity. In order to diminish side effects and newlineresistance caused by cisplatin, other metal-based drugs are being investigated. newlineIn the past few decades, the natural products (with no or least side effects) are newlinebeing exploited for developing effective anti-cancer drugs, especially, by modifying newlinetheir molecular structures. Among several natural products, the active constituent of newlinequinoxaline is used as precursor for developing various medicines. It is due to its fair newlinepharmaceutical properties including anticancer. newlineCopper containing proteins were found widely distributed in both plants and newlineanimals and performed in a diverse array of functions such as hydroxylation, oxygen newlinetransport, electron transfer and oxidative catalysis. Hence, the coordination chemistry newlineof copper (II) attracts much attention because of its biological relevance and its own newlineinteresting coordination chemistry such as geometry, flexible redox property, and newlineoxidation state. Nowadays, coordination compounds have been known to be useful in newlineconstructing molecular information processing systems, particularly by biological newlineself-organizing p