Synthesis Characterization and Pharmacological Evaluation of 3 And 5 Disubstituted 2 4 Thiazolidinedione Derivatives

Abstract

Among a number of heterocyclic rings, the thiazolidinedione ring system and newlineespecially, 2, 4-thiazolidinedione (2,4-TZD) 1 has long been investigated as the key newlinepharmacophore for synthesizing various drugs having varied biological activities. This newlineis a 5-membered heterocyclic ring having nitrogen, sulphur and carbons as the newlinemembers of the ring and two carbonyl groups at 2nd and 4th positions are present as the newlinepart of the amide and thiocarbamate. The carbonyl groups of 2, 4-thiazolidinedione are newlinehighly stable and unreactive. The positions where substitution can be done are newlinemethylene carbon (3rd position) and Nitrogen (5th position) to develop novel potential newlineanalogues for various therapeutic interventions. The thiazolidinediones were introduced newlinein the late 1990 as effective antidiabetic agents for the treatment of diabetes mellitus newlinetype 2 but now are under investigation for its various other pharmacological activities. newlineA variety of research papers proved the versatility of 2, 4-TZD as anticancer, newlineantimicrobial, antiarthritic, anti-inflammatory, antioxidant etc. newlineCancer is found to be the major cause of deaths newline