Monodispersed Magnetic Fluid Synthesis Characterization And Applications

Abstract

Magnetic Fluid Hyperthermia (MFH) is emerging as a promising cancer therapy because of its advantage as a less painful and more targeted treatment option. With iron oxide nanoparticles-based magnetic fluid, it is difficult to control the hyperthermia window temperature (315 319 K). Temperature-sensitive magnetic fluids offer an advantage due to their low Curie temperature, and as a result, they can be used as self-regulating switch. Mn0.5Zn0.5Fe2O4 has a low Curie temperature (370 K), high saturation magnetization (210 kA/m), and a high pyromagnetic coefficient, making it attractive for MFH. The present study reports the hydrothermal/solvothermal method to prepare monodispersed Mn0.5Zn0.5Fe2O4 nanoparticles with different shapes (nanoflowers, octahedrons, cubes, rings, and rods) to explore their MFH response. newlineThe findings clearly indicate that particle shape significantly affects heating efficiency. Among the measurements, nanorods with a higher aspect ratio have the maximum SAR of 781.7 W/gmag, demonstrating superior MFH efficacy, followed by nanoflower with SAR of 360.9 W/gmag. In contrast, nano cube, ring, and octahedron exhibit moderate SAR values ranging from 123.9 to 225.7 W/gmag, and nanorod with a smaller aspect ratio present the lowest SAR of 99.3 W/gmag. The findings indicate that shape anisotropy plays a crucial role in enhancing heating efficiency for MFH applications. newlineThe A55HT16 nanoflower was further tested for an in vitro MFH study on MDA-MB-231 breast cancer cells because of its maximum pyromagnetic coefficient among other samples. Results showed 87% cell death within 40 min (309 kHz, 23.87 kA/m), outperforming the single-domain nanoparticles. newlineOverall, the hydrothermal method enables controlled synthesis of shape-specific Mn0.5Zn0.5Fe2O4 magnetic fluids with shape-dependent heating efficiency and stability, making them strong candidates for safe and effective MFH. newlineKeywords: Monodispersed, Magnetic fluid, Hydrothermal method, Different shapes, Magnetic fluid hyperthermia, SAR.