Variants in the genes of Interleukins Fc receptor like protein 3 FCRL3 and Group 2 Secretory Phospholipase A2 SPLA2 IIA and their association with endometriosis

Abstract

Endometriosis is a multifactorial disease involving genetic hormonal immunological and environmental components The polymorphisms in IL 4 IL 18 FCRL3 and SPLA2IIa genes were analysed to identify any significant association with endometriosis This study evaluated the polymorphisms of IL 4 gene rs 2243250 IL 18 gene rs1946518 FCRL3 gene rs 7528684 and sPLA2IIa gene rs11573156 in women with endometriosis The case control study included 150 women with endometriosis as cases and 150 apparently healthy women as control subjects The study was carried out to analyse the relationship between gene polymorphisms and endometriosis To evaluate the association between the different genotypes 95 Percentage confidence intervals CI were calculated Also an equal number of serum samples N equal to 40 were collected from both groups to estimate the concentration of cytokines IL 4 and IL18 using ELISA method The IL18 and FCRL3 gene polymorphisms in endometriosis showed significant association P less than 0point0001 when compared with controls However there was no significant difference in IL 4 and sPLA2IIa gene polymorphisms in endometriosis The concentrations of both IL 4 and IL 18 serum levels were significantly higher in endometriosis when compared to controls P less than 0 point 005 The present study suggests that the IL 18 and FCRL3 gene polymorphisms are associated with endometriosis However a larger sample size of patients from various ethnic backgrounds is necessary to evaluate whether these genes have a direct effect on disease susceptibility newline