Insulin resistance oxidative stress and inflammatory markers in women with polycystic ovary syndrome

Abstract

Polycystic ovary syndrome (PCOS) is a common health problem which newlineis alarmingly increasing in teenage girls and young women during their early newlinereproductive years. It is one of the most common treatable endocrine newlinedisorders of women in reproductive age with prevalence of 4-12% globally. In newlineIndia the prevalence of PCOS is 2.2%-26%. About 5-10% of premenopausal newlinewomen are also affected by PCOS and it is a rising and burning problem with newlinestudies confirming the relationship between obesity, anovulation, newlinehyperandrogenism, chronic low grade inflammation, insulin resistance,metabolic syndrome, diabetes mellitus, hypertension and cardiovascular newlinedisease and PCOS. newlineHence, there is a need to evaluate the circulating concentrations of newlinebiochemical markers of inflammation, oxidative stress in obese women with newlinePCOS for early detection, better understanding about the cause of PCOS and newlinethe treatment. newlineIn conclusion the newlinestudy showed significant difference in terms of biochemical markers like newlineincreased CRP, MDA, visfatin and decreased serum levels of adiponectin and PON1. There was significant difference in terms of hormones with increased newlineserum levels of LH, testosterone, estrogen, AMH, DHEAS and decreased newlinelevels FSH, SHBG. However prolactin did not show any difference. The newlinepresent study did not show significance in factors like fasting blood sugar, newlineinsulin and insulin resistance, which are considered as risk factors for the newlinedevelopment of diabetes mellitus. Dyslipidemia was detected only in terms of newlineserum total cholesterol and total triglycerides. newline