A comparative study of novel biomarkers and oxidative stress in preeclampsia

Abstract

Preeclampsia is an idiopathic disorder and it is speculated that the newlineoccurrence may increase in obesity and overweight. An important risk factor newlineof preeclampsia and cardiovascular disease attributed to be high body mass newlineindex (BMI) (Bodnar et al, 2007). Worldwide prevalence of obesity is newlineincreasing at a very faster rate. The global obesity epidemic affecting women newlineof reproductive age is a major contributor to adverse pregnancy (Yu et al, newline2013). Excessive gestational weight gain may have an association with newlineadverse birth and pregnancy outcomes (Chung et al, 2013). Among newlineEuropean women prevalence of obesity ranges from 10 25%. A study newlinesuggested that extremely obese women are at fourfold risk of developing newlinepreeclampsia compared to normal weight women (Knight et al, 2010). These newlinestudies showed diverging results, with some showing that obesity and newlineoverweight are risk factors for late, but not early, preeclampsia. Very few have newlineinvestigated the effects of maternal BMI on risks of preeclampsia separately. newlineThe relationship between gestational BMI and preeclampsia is still newlineinconclusive and also whether maternal weight could predict the severity after newlinepreeclampsia has already developed is still not clear. Whatever be the reason newlineand cause of obesity and overweight in pregnant women, it should not newlineadditionally cause the alteration in the biochemical markers. newlineTherefore the present study was undertaken to see the association of newlineBMI with nitric oxide (NO), L arginine, Endothelial nitric oxide synthase newline(eNOS), Asymmetric dimethylarginine (ADMA), placental growth factor newline(PlGF), soluble Fms-like tyrosine kinase-1(sFlt1), Soluble Endoglin (sEng), newlinecomplete haemogram, renal function, electrolytes, lipid profile, liver function newlinetests parameters, enzyme profile and oxidative stress in healthy pregnant and newlinepreeclampsia women to have a better insight and better understanding of newlineetiology and pathophysiology of preeclampsia. And also any of the newlineparameters can be used as novel biomarkers for the early detection of PE