comparative evaluation of submucosal diclofenac and dexamethasone preemptive analgesia for post operative pain management in patients undergoing third molar surgery a randomized controlled trial

Abstract

Background newlineThird molar removal is the frequently performed procedure in oral and newlinemaxillofacial surgery, typically involving flap reflection, bone removal, newlineand root separation, which can potentially induce trauma to the newlineadjacent soft and bony tissues involving flap reflection, bone removal, newlineand root separation, which can cause trauma to the surrounding soft newlineand bony tissues, resulting in complications such as edema, trismus, newlinepain, and alveolar osteitis that extend the recovery period. By newlineinhibiting phospholipase A2 activity, these agents effectively reduce newlinethe levels of prostaglandins and leukotrienes, key contributors to the newlinedevelopment of edema, trismus, and pain. Numerous studies have newlineestablished a clear correlation between the complexity of tooth newlineremoval and postoperative discomfort. To alleviate these issues, it is newlinecommon practice to use NSAIDs and steroids, as substantial doses of newlineanalgesics, including opioids and nonsteroidal anti-inflammatory newlinedrugs (NSAIDs), are typically required for adequate pain relief. newlineHowever, it is crucial to acknowledge the potential risks, such as newlinepostoperative gastritis and prolonged drug administration, associated newlinewith these medications. Therefore, the recommended approach newlineinvolves preemptive submucosal administration of newlineanalgesic-anti-inflammatory agents, along with continuous monitoring newlineduring the initial week after surgery, to optimize patient outcomes. newline newline