Studies on bioactive tetrahydro pyrimidine

Abstract

Heterocyclic compounds have drawn special attention in organic chemistry because of their abundance in natural products and their diverse biological properties. Pyrimidine and its derivatives have been recognized as important heterocyclic compounds due to their variety of chemical and biological significance to medicinal chemistry. Pyrimidines have a long and distinguished history extending from the days of their discovery as important constituents of nucleic acids to their current use in the chemotherapy of acquired Immuno Deficiency newlinesyndrome (AIDS). The pyrimidine nucleus is embedded in a large number of alkaloids, drugs, antibiotics, agrochemicals and antimicrobial agents. In the past decades, a broad range of biological effects, including antiviral, antitumor, antibacterial and anti-inflammatory activities, has been ascribed to partly reduced pyrimidine(DHPM) derivatives.More recently, appropriately functionalized DHPMs have emerged as eg. Orally active antihypertensive agents. M. D. Gavilan et al reported the synthesis of (tetrahydro-4-,1-benzoxazepine-3-yl) pyrimidines and evaluated for anticancer activity, these compound showed significant antitumor activity (IC50=1.25-6.75and#956;M on MCF-7cell.) Some other researchers also prepared pyrimidine derivatives and tested their antitumor and anticancer activities. As a result of remarkable pharmacological activity of pyrimidine derivatives , in continuous of our earlier work, we have synthesized 1,2,3,4-tetrahydro pyrimidine derivatives and studied their antimicrobial activity. 1,2,3,4 Pyrimidine antagonists belong to the group of antimetabolite anti- cancer drugs and show structural resemblance with naturally occurring nucleotides. Their action is accomplished through incorporation as false precursor in DNA or RNA or through inhibition of proteins involved in nucleotide metabolism.