Cross linked biopolymeric beads used as a pharmaceutical carrier for oral controlled drug delivery system

Abstract

The physiology of the gastrointestinal tract presents serious barriers and challenges to oral drug delivery. The wide intra- and intersubject variability of gastrointestinal transit time is an important factor that can have a significant influence on drug bioavailability. Mucoadhesive formulations can increase and harmonize the passage time through the gastrointestinal tract, with the potential benefit of more reproducible drug bioavailability. This effect can be enhanced by using multiparticulate drug delivery system instead of single-unit dosage forms as the gastrointestinal transit of the formers is more reproducible and predictable. The present study aims to investigate the efficacy of the novel biopolymeric complex multiparticulate system consisting of chitosan succinate (CS) and sodium alginate (SA) and carboxy methyl cellulose (CMC) as a pharmaceutical carrier showed promising attributes to be considered to deliver the drug at the targeted site of colon carcinogenetic cells. By improving the site specific delivery, it holds a greater possibility to decrease the dose frequency and lower side effects. newline