Investigation on synthesis and physicochemical characterization of biopolymer embedded hydroxyapatite composites with mmt clay silane metal oxide for biological and environmental applications

Abstract

Animal bones comprising hydroxyapatite (bio-ceramic) are newlineregularly viewed as a natural resource for hydroxyapatite. Hydroxyapatite is newlinethe major component present in bone minerals, has remarkable properties due newlineto its bioactivity and biocompatibility. Fish bone is a natural bio-waste newlinecontains calcium phosphate act as main constituent for hydroxyapatite. newlineIn this present study, hydroxyapatite has been prepared from fish newlinebone waste using the thermal calcination method. Biopolymer incorporated newlinecomposites have been designed for effective use in biological applications newlinesuch as antioxidant, drug release, etc. To enhance the biological importance of newlinehydroxyapatite obtained from fish bone waste, it was integrated with the newlinesodium alginate biopolymer and montmorillonite clay using the co newlineprecipitation method. The synthesized composites were investigated for newlineantioxidant, antidiabetic and drug releasing behaviour. newlineFurther, hydroxyapatite was modified with aminopropyltriethoxy newlinesilane and blended with a different proportion of sodium alginate. The drug newlineloading and releasing efficiency of composites were assessed at various pH. newlineThe cytotoxic studies and hemolytic activity validated that the composite was newlinebiocompatible. newlineThe environmental applications of hydroxyapatite are enhanced by newlineincorporating with manganese dioxide and chitosan. The primary focus of this newlinecomposite was to evaluate its effectiveness for the photodegradation of dyes newlinewith various parameters. newline