Comparison of effectiveness of morus alba and Chlorhexidine gels on moderate periodontitis Among 35 to 55 year old subjects a hospital Based randomized controlled trial

Abstract

Background: Periodontal disease is one of the two major dental diseases affecting newlinehuman population. As per the World Health Organization report, 80% of the newlinepopulations of developing countries rely on traditional medicines, mostly. newlineantimicrobial agents have been and are being tested throughout the world in order to newlinedetermine which derivatives are effective and safe to be used as preventive newlineformulation to stall dental plaque formation and/or to stop the colonization of disease newlinecausing microorganisms. Morus alba is one such plant which has a long history of newlinemedicinal use in traditional Chinese medicine. newlineAim: The aim of the present study was to assess and compare the effectiveness of newlineMorus alba gel with Chlorhexidine gel on Moderate periodontitis among 35 to 55 newlineyear old subjects. newlineMaterials and Methods: A Concurrent Parallel Randomized Controlled Clinical newlineTrial was conducted at KLE VK Institute of Dental Sciences, Belagavi, India. The newlineclinical trial was registered at Clinical Trial Registry India before the recruitment of newlinefirst subject. A total of 30 subjects were selected based on the inclusion and exclusion newlinecriteria. The subjects were randomly divided into study and control group having 60 newlineperiodontal pockets each. Clinical and microbial parameters like Gingival index, newlinePlaque index, Periodontal pocket depth (PPD), number of periodontal microorganisms newlinefrom subgingival plaque sample were assessed. On the same day of recruiting the newlinesubjects, Scaling, Root planning and Curettage were completed. Respective gels were newlineadministered 3 times with an interval of 15 days. Final assessment was done at the newlineend of 45 days from the baseline examination. Data was entered in Microsoft excel newlineXXI newline newlineNumerous newline newline newlineand analyzed using SPSS version 20 (SPSS Inc. California, USA). Chi-square test, newlineMann whitney U test and Wilcoxon sign rank test were used for statistical analysis. newlineResults: Mann Whitney U test showed that there was no statistically significant newlinedifference in the Plaque, Gingival and PPD score