Evaluation Of Different Fluoroquinolone Fq Antibiotics For Detection Of Low Level Fluoroquinolone Resistance In Salmonella Enterica Serovars Typhi And Paratyphi A

Abstract

This study is important as previous studies have proposed a breakpoint of FQ using non- typhoidal Salmonella with diverse resistance mechanisms. This study suggests that the currently proposed breakpoint of and#707; 0.06 and#956;g/mL for ciprofloxacin fails to detect isolates with decreased ciprofloxacin susceptibility (DCS) irrespective of different FQ resistance mechanism. The tentative breakpoint for susceptible established in our study with minimum errors and and#707; 95 % CA were found to be and#8805;28 mm and and#8805; 25 mm for levofloxacin and ofloxacin respectively. newlineThe performance of nalidixic acid was poor as it failed to detect isolates with DCS mediated by gyrB mutation which are now emerging in India developing countries and UK. These isolates are typically sensitive to nalidixic acid. newlineSalmonella is associated with various clinical syndromes. Antimicrobial therapy is important for the management of invasive infections with nontyphoidal Salmonella and typhoidal Salmonella (S. enterica serovars Typhi and Paratyphi). newline