Development of Novel Metal Organic Framework MOF Based Electrodes for Glucose Detection Towards the Diagnosis of Diabetes Mellitus

Abstract

Glucose sensors can contribute to effective diabetes management, facilitate medical newlineresearch, and improve the quality of life for individuals living with diabetes. Growing newlinedemand for compact, portable glucose sensors that can be integrated into wearable devices newlineor handheld meters has been increasing. Miniaturization allows for convenient, on-the-go newlinemonitoring, enabling individuals to manage their glucose levels more effectively. In this newlinedissertation, MOF based electrodes are fabricated and integrated with gate of n-MOSFET newlinetowards the detection of glucose for invasive and non-invasive diagnosis of diabetes newlinemellitus. newlineAt first, we prepared ZIF-67 derived Co3O4 dodecahedrons using precipitation and newlinecalcination method. Hollow Co3O4 dodecahedrons with an average particle size of Co3O4 of newline1.72 and#61549;m was identified using HR-SEM images. Fabricated electrode (Co3O4 dodecahedrons newlinecoated on Cu foil with PVDF as binder) showed wide range of glucose detection from 1.5 newlinemM to 42 mM with fast response time of and#706;4s and sensitivity value of 50 and#61549;A. mM-1cm-2. newlineWith regard to other interfering molecules such sucrose, lactose, fructose, uric acid, and newlineascorbic acid, our fabricated electrode has shown an excellent selective response. Scanning newlineKelvin probe (SKP) has been used to examine how glucose concentration affects the surface newlinepotential of the fabricated electrode. We have discovered that increasing the glucose newlineconcentration causes the work function to decline. According to the EGFET and SKP newlineexperiments, a Co3O4 dodecahedron-shaped microparticle-based electrode derived from newlineZIF-67 is appropriate for quickly detecting glucose in human blood newline