Electrophysiological abnormalities in multiple sclerosis

Abstract

This study has helped to analyse the various patterns of electrophysiological abnormalities seen in MS, especially pertaining to our Indian population. We have also analysed in detail, the relationship between symptomatology, duration and severity of the MS with various electrophysiological abnormalities. We have investigated the interrelationship of cognitive dysfunction among patients with MS with event related newlinepotentials. P300 potentials showed a significant correlation with cognitive rather than newlinephysical fatigue in our sample. PNCS have demonstrated that a significant number of newlineindividuals do have peripheral nerve abnormalities also. Polysomnography has proved to newlinebe a useful tool to assess the quality of sleep in people with MS, and did show newlinecorrelation with cognitive fatigue. This study has also helped develop a continuous newlineinterval scaled objective scoring system the CEP score to quantify the disease burden newlinein subjects with MS which can be used in clinical as well as research purposes. Electrophysiological measures show a strong correlation with many of the newlineclinical manifestations of multiple sclerosis like measures of gait and balance, number of newlinefalls, cognitive impairment, cognitive fatigue, and sleep impairment. A small number of newlinepatients also had peripheral nerve abnormalities like prolonged CMAP, SNAP or F wave newlinelatency, reduced CMAP or SNAP amplitude. Hence, it is prudent to assume that newlineelectrophysiological investigations still are highly relevant in the diagnosis and newlinemanagement of MS related comorbidities. newline newline