Investigations on metal ions doped nano crystalline

Abstract

newlineBiomaterials are used to make devices to replace part of a living newlinesystem or to function in intimate contact with living tissue without being newlinerejected by the body It has used every day in biomedical applications such as newlinehard tissue replacement facial surgery and drug delivery In general newlinebiomaterials are classified into four major groups metals polymers ceramics newlineand composites Bioceramics has found applications for replacing several newlineparts of our body such as hip knee ankle elbow and other joint damages newlinewith subsequent limited basic activities Bone is a complex living tissue newlinewhich has elegant structures at a range of different hierarchical scales It is a newlinecomposite of organic and inorganic materials which forms the basis of the newlineskeleton and its functions are numerous and complex The organic compound newlineis composed mainly of type I collagen fibers and occupy 3035 of bone by newlineweight The inorganic portion of bone is calcium phosphate compound which newlinehas 6570 hydroxyapatite HAp HApbased ceramic is the main inorganic newlinecomponent of hard tissues like bone and dental reparation and also for the newlineapplications in drug delivery systems newlineOsteosarcoma is one of the bone tumors which can be remedied by newlineusing magnetic nanoparticles Magnetic nanoparticles are subjected to newlineoscillating magnetic field that absorbs energy from the electromagnetic wave newlineand may show remarkable heating effects The temperature can be maintained newlinein a cancerous tissue within the range of 42 46 C for 30 min or more thus newlinecancer cells are destroyed Substitution of Ca2 in HAp by magnetic ions or newlinemetal ions could be useful for biological applications such as magnetic newlineresonance imaging MRI cell separation targeted drug delivery and heat newlinemediator for the hyperthermia treatment of cancer newlineSurface modification through ion irradiation is an important tool for newlinethe ceramic materials also to improve the bulk properties and sterilization newlineThe irradiation method enables us to modify the chemistry of HA p in a newlinereproducible way so as to optimize the bone newline newline