Exploring leishmania biochemistry to understand effect of spermidine starvation and identification of novel drug candidates

dc.contributor.guide	Dubey, Vikash Kumar
dc.coverage.spatial	Biosciences and Bioengineering
dc.creator.researcher	Singh, Shalini
dc.date.accessioned	2023-05-10T06:32:55Z
dc.date.available	2023-05-10T06:32:55Z
dc.date.awarded	2015
dc.date.completed	2015
dc.date.registered	2011
dc.description.abstract	Leishmaniasis is caused by different species of Leishmania In order to develop a better drug candidate we chose to explore two different pathways of Leishmania redox metabolism and protein prenylation pathway Spermidine synthase a key enzyme for second step of redox metabolism pathway of parasite catalyzes formation of spermidine We have identified hypericin as a novel inhibitor of spermidine synthase of Leishmania donovani Hypericin has shown significant antileishmanial activity with IC
dc.description.note	Not Available
dc.format.accompanyingmaterial	None
dc.format.dimensions	Not Available
dc.format.extent	Not Available
dc.identifier.uri	http://hdl.handle.net/10603/482076
dc.language	English
dc.publisher.institution	DEPARTMENT OF BIOSCIENCES AND BIOENGINEERING
dc.publisher.place	Guwahati
dc.publisher.university	Indian Institute of Technology Guwahati
dc.relation	Not Available
dc.rights	self
dc.source.university	University
dc.subject.keyword	Biotechnology and Applied Microbiology
dc.subject.keyword	Life Sciences
dc.subject.keyword	Microbiology
dc.title	Exploring leishmania biochemistry to understand effect of spermidine starvation and identification of novel drug candidates
dc.title.alternative	Not available
dc.type.degree	Ph.D.