Design optimization and characterization of dapagliflozin loaded nanostructured lipid carriers dp nlc and polymeric nanoparticles dp pnp using boxbehnken

Abstract

newlineDapagliflozin Used to improve glycemic control, along with diet and exercise, in newlineadults with type 2 diabetes is the model drug selected in the present research titled newlineDesign, Optimization, Characterization of Dapagliflozin Loaded Nano particulate newlinesystems Using Box-Behnken Design. Nano formulations are capable of providing newlinesite-specific delivery of anti-diabetic molecules to their specific site of action; this newlineenhances the loco-regional concentration of the drug and reduces the systemic sideeffects. newlineDapagliflozin loaded NLCs and polymeric nanoparticles were prepared by newlineemulsion evaporation technique. The prepared Nano particulate formulations were newlinecharacterized for particle size, zeta potential, entrapment efficiency and percentage newlinedrug release. The effects of composition of lipid materials and surfactant mixture and newlinehomogenization speed on the particle size, zeta potential, drug entrapment efficiency, newlineand in vitro drug release behavior were optimized. The optimized formulations OPTDP- newlineNLC and OPT-DP-PNP has shown a particle size and entrapment efficiency of newline69.99nm, 81.94%, and 132.23±7.26nm, 92.16±2.17% respectively. Hence, we can be newlineconcluded that the Dapagliflozin can be potentially delivered with high bioavailability newlinethrough Nano particulate systems. newlineKeywords---Dapagliflozin, NLC, Polymeric Nanoparticles, Box-Behnken design, newlineParticle Sizes, Entrapment Efficiency and Drug Release. newline