Design Synthesis and Anticancer Evaluation of Quinoline Based Derivatives

Abstract

he thesis entitled Design, Synthesis and Anticancer Evaluation of newlineQuinoline Based Derivatives has been divided into Eight chapters. newlineThe knowing all aspects and importance of bioactive quinoline derivatives, we newlinehave investigated new methods for the synthesis of some bioactive quinolines using newlineammonium metavanadate and lanthanum chloride catalyst. newlineFirst chapter deals with the general introduction of quinoline based derivatives newlineand its importance as anti-cancer agents. newlineSecond chapter describes the synthesis of quinoline-3-carbonitriles. newlineThird chapter deals with the synthesis of bio-active indeno[1,2-b]quinolin-7- newlineones. newlineFourth chapter describes the synthesis of indeno[1,2-b]quinoline-9,11-dione newlinederivatives. newlineThe synthesis of chromeno[4,3-b]quinolin-6-one derivatives are studied in newlinechapter 5. newlineChapter six deals with the synthesis of quinoline-4-carboxylic acid derivatives. newlineChapter seven contains the synthesis of polysubstituted quinoline derivatives. newlineChapter eight describes the anticancer activity evaluation of all synthesized newlinebioactive quinoline derivatives. newlineChapter 1: Introduction newlineChapter 2: Synthesis of 2-Amino-4-arylquinoline-3-carbonitriles newlineRecently quinoline derivatives especially quinoline-3-carbonitriles have newlinereceived a strong research interest because of their potent biological and newlineAbstract newlineiv newlinepharmacological properties such as antimicrobial, anticancer, anti-malerial, cytotoxic, newlineanti-proliferative, DNA binding properties, and inhibitors for phosphodiesterase type newline4B enzyme. newlineThis chapter includes an efficient protocol for the synthesis of quinoline-3- newlinecarbonitrile derivatives by the reaction of aromatic aldehydes, aniline and newlinemalononitrle in presence of catalytic amount ammonium metavanadate in solvent newlineethanol at room temperature condition (Scheme 1). newline1 2 newline+ newlineNH2 newlineR2 newline+ newlineCHO newlineR1 newline3 newlineCN newlineCN N NH2 newlineCN newline4a-j newlineR1 newlineR2 newlineNH4VO3 newlineEtOH, rt newlineScheme 1 newlineChapter 3: Synthesis of Indeno[1,2-b]quinolin-7-ones. newlineThe quinoline skeleton is present in many biologically active compounds and newlineis frequently condensed with other heterocycles. Synthesi