Safety Studies of Hydroxyapatite Nanoparticles and Polymer Coated Hydroxyapatite Nanoparticles on Drosophila Melanogaster

Abstract

Hydroxyapatite (HAp), is a member of the apatite family comprising of Ca/P ratios ranging from 1.57 to 1.67. The exceptional biocompatibility and biodegradability properties have been broadly used in biomedical applications and other purposes such as drug delivery, bone tissue engineering etc. HAp NPs have been combined with different polymeric materials to overcome the limitations such as poor loading properties, and higher flexibility. Studies have reported that HAp NPs caused developmental delays in adult flies and zebra fish models. Therefore, augmented use of HAp NPs warrants the study of its toxic effects in in vivo models. newlineChitosan (CS), is a naturally occurring polymer that is obtained by the deacetylation of chitin commonly present in the shells of crustaceans, insect cuticles etc. Its biodegradable, antimicrobial and antioxidant properties have been the primary reason to be used in several fields such as tissue engineering, biology, food, and pharmaceutical industries. Chitosan has been used against acrylamide (ACR) induced toxicity in Drosophila melanogaster. Herein,