Design synthesis and studies on the photophysical properties of unnatural c triazolyl aryl fused n triazolyl nucleosides and hybridisation accompayning fret event in another set of chimeric dna duplexes

Abstract

In short Chapter 1 is a review on the synthesis of unnatural C nucleosides Chapter 2 deals with the cobalt catalyzed conversion of 1 206 177 ethynyl sugar to 1 206 178 ethynyl sugar followed by the synthesis of C triazolyl 206 178 nucleosides cTBDo Ac and their photophysical study In Chapter 3 the synthesis of an angularly expanded compact hydrophobic Fused triazolyl phenanthrene unnatural nucleoside FTPhen and its photophysical properties are described In addition its DNA duplex stabilization within a