Design synthesis and characterization of B lactams other heterocycles and their functionalization using nanocatalysts

Abstract

This thesis presents a comprehensive study on the design, synthesis, and characterization of Schiff bases, and#946;-lactams, and a range of other heterocyclic frameworks, with a particular focus on their functionalization through nanocatalystassisted organic transformations. Building on recent advancements in these domains, the work introduces innovative synthetic strategies aimed at generating structurally diverse and functionally rich molecules. Extensive experimental efforts were undertaken to characterize the synthesized compounds using various analytical techniques. The developed methodologies were validated through broad substrate scope evaluations and supported by detailed analytical data. Mechanistic insights were proposed based on experimental evidence to elucidate the underlying transformation pathways. In addition, selected compounds were assessed for their sensory properties and biological activities. These were further complemented by theoretical studies, including density functional theory (DFT) calculations and in-silico molecular docking analyses, to provide a deeper understanding of their electronic behavior, binding interactions, and pharmacological potential. newline