Pharmacological Evaluation of Cocoa on Efficacy and Toxicity of Doxorubicin in Murine Ascites and Solid Tumor

Abstract

Background: Doxorubicin (DOX) is an extensively utilised chemotherapy drug, newlineoxidative stress caused by it can damage the heart, liver, and kidneys. Theobroma newlinecacao L. (cocoa) is reported to possess protective efficacy against several chemical- newlineinduced organ damages and also anticancer activity. The present study aimed to newlineevaluate the effect of cocoa extract (COE) on doxorubicin-induced organ damage in newlinemice with Ehrlich ascites carcinoma (EAC) by employing in silico, in vitro, and in newlinevivo studies. newlineObjective: newline1. To assess protective activity of cocoa against Doxorubicin induced organ newlinetoxicities (Heart, Liver and Kidney) in a mouse bearing ascites and solid tumor newline2. To assess Cytotoxic activity of Doxorubicin in combination with cocoa in a newlinemouse bearing ascites and solid tumor newline