Studies on nootropic effects of various extracts of Gemlina arborea and Cayratia trifolia

Abstract

quotNeurodegenerative disorders, especially Alzheimer s disease (AD) is a serious global health problem. Current scenario of pharmacological treatment of dementia or AD is not satisfactory, as there is no cure for AD with existing medication. newlineThe extensive literary survey was conducted and the plants Gmelina arborea and Cayratia trifolia were selected for the investigations. newlineThe in vivo models used for the study of nootropic activity of extract of Gmelina arborea and Cayratia trifolia were step down passive avoidance, conditioned avoidance response, sodium nitrite induced amnesia and elevated plus maze, while in vitro models includes antioxidant activity by DPPH, NO, estimation of brain reduced glutathione (GSH), estimation of acetyl cholinesterase enzyme activity in mice brain, estimation of brain total protein and estimation of catalase activity. newlineInvestigation marvelously demonstrates the cognitive enhancing and/or anti-amnesic property of the plant preparations in the presence and/or the absence of amnestic agent suggests the nootropic activity of plant preparation of Gmelina arborea and Cayratia trifolia comparable to piracetam. newlinequot newline newline