Formulation Development and Evaluation of Torsemide Solid Dispersion for its Bioavailability Enhancement

Abstract

xxii newlineABSTRACT newlineTorsemide is high-ceiling loop diuretic, It is recommended for the management of oedema brought on by renal, hepatic, or congestive heart failure conditions. The Torsemide is poorly soluble in aqueous medium. Solid dispersion particularly aims at enhancing the solubility of poorly water-soluble drugs by the use of solid solubilises. A combination of solubilizers can be used to enhance the solubility of the drug leading to reduction in individual concentrations of solubilises and effective enhancement of solubility of the drug. Torsemide was incorporated into solid dispersion using random combination of several solubilizes. The solubilizers were dissolved in water and then drug was added, a clear yellow solution was formed. The excess water was evaporated from this solution and solid dispersion was obtained which was later dried completely, pulverized and packed, A combination of solubilises can be used to enhance the solubility of the drug. Solid dispersion is prepared in three different batches SDA, SDB, SDC with different ratio (1:4,1:5,1:6 ratios) by using, accurately weighed sodium caprylate , beta cyclodextrin, sodium citrate, sodium acetate, water and torsemide and temperature was maintained in the range of 70- 80C ,and#1455;Solid Dispersion was evaluated by Micromeritic Properties of Solid Dispersions, Powder X-Ray Diffraction Studies, Scanning Electron Microscopy, Dissolution Rate Studies, SDA batch showing satisfactory result. Mouth Dissolving Tablet, was prepared by Torsemide (Solid Dispersion), Crospovidone, Sodium starchglycolate, Mannitol, Mg. Stearate, Talc, Aspartame in eight different batches(T1-T8 formulations) and the tablets were evaluated by pre-compression characteristics of powder blend, weight variation test, thickness test, hardness, friability, drug content, wetting time, Water absorption ratio, disintegration time. From the result it has been observed that T7 formulation exhibited excellent wetting time, water absorption ratio and disintegration time as compared to newlinexxiii newlineother form