Comparative Evaluation Of Antimicrobial Activity Of Different Nanoparticles Through Functionalization Of Silicone In The Patients With Maxillary Defect An In Vivo Study

Abstract

newlineIntroduction: newlineA maxillofacial prosthesis is designed to replace absent oral or facial structures along with their associated functions. The surfaces of maxillofacial prostheses are composed of silicone and directly come in direct approximation with saliva, soft tissues and nasal secretions. Contact with these bodily fluids may result in the colonization of diverse microorganisms on surfaces, potentially leading to the deterioration of the silicone elastomer or the risk of infection Nanodentistry is the quotscience and technology of diagnosing, treating, and preventing oral diseases, alleviating pain, and preserving and enhancing dental health through the utilization of nanostructured materials.quot newlineMethod: newlineThis study involved 45 patients undergoing maxillary surgical interventions (either for developmental or acquired defects), where interim obturators were chosen as the preferred rehabilitation prosthesis. Total number of patients randomly selected in 3 groups out of which 1st group ie Group A is control group and 2nd group ie Group B is Experimental group with Hybrid nanoparticles and 3rd group ie Group C is Experimental group with Chitosan nanoparticles. Swab was taken from the intaglio surface of prosthesis in a pre-decided interval Result: newlineThe findings indicate that relining an interim obturator with hybrid nanoparticles (Group B) exhibits greater effectiveness compared to relining with a chitosan-incorporated interim obturator (Group C) and conventional interim obturator (Group A). newlineConclusion: newlineThe findings from this study indicate that the Experimental Group B, which involved obturator relining with silicone material containing hybrid nanoparticles, demonstrated superior antimicrobial efficacy over a range of time intervals up to 6 weeks. This was in comparison to Group C, the Experimental Group where obturator relining involved silicone material containing chitosan nanoparticles. Group A, the control group utilizing conventional interim obturator, showed comparatively lower efficiency in anti