comparative study on neuromuscular blockade action of calcium channel blockers in wistar rats

Abstract

In this comparative study, we investigated the neuromuscular blockade action of newlinecalcium channel blockers (CCBs) using three different models: the inclined screen newlinemethod, rotarod test, and gait test in Wistar rats. newlineObjectives: newlineStudy 1: Comparison of neuromuscular blockade action of Verapamil and newlineBenidipine in Wistar rats. newline To assess the neuromuscular blockade effects of verapamil and benidipine, two newlinecalcium channel blockers, using the inclined screen method. newline To evaluate the motor coordination and neuromuscular effects of verapamil and newlinebenidipine using the rotarod test. newline To analyse the gait patterns and detect potential neuromuscular blockade newlineinduced by verapamil and benidipine using the gait test. newline To compare the effects of different doses of verapamil and benidipine on the newlineneuromuscular blockade in the three models. newline To investigate the dose-dependent response of verapamil and benidipine on the newlineneuromuscular blockade in Wistar rats. newline To assess the impact of Pancuronium, Verapamil, and Benidipine on newlinehaematological parameters in albino rats. newline By addressing these objectives, the study aimed to provide insights into the newlineneuromuscular effects of verapamil and benidipine, contributing to understanding newlinetheir potential as calcium channel blockers and their impact on motor function newlineand coordination. newlineStudy 2: Comparison of neuromuscular blockade action of Amlodipine and newlinediltiazem in Wistar rats. newline To assess the neuromuscular blockade effects of Amlodipine and diltiazem, two newlinecalcium channel blockers, using the inclined screen method. newline To evaluate the motor coordination and neuromuscular effects of Amlodipine and newlinediltiazem using the rotarod test. newline newline