Green Synthesis of Zinc Oxide Nanoparticles from Eclipta Prostrata Against Oral Pathogens and Oral Matrix Metalloproteinases

Abstract

newlineABSTRACT newlineThe present study outlines the development of a method to synthesize zinc nanoparticles ZnNPs by mixing zinc acetate solution with leaf extract of Eclipta prostrata without using any surfactant or external energy. Eclipta prostrata leaf extract function as an excellent reducing agent of zinc ions, and the biosynthesized ZnNPs are safer for the environment. The powder X-ray diffraction pattern provided evidence for the formation of facecentered cubic structure ranging from 23 to 57 nm with an average size of 31 nm. Fourier transform infrared spectroscopy was used to identify the biomolecules and capping reagents in the Eclipta prostrata leaf extract that may be responsible for the reduction of zinc ions and the stability of the bioreduced nanoparticles. The biosynthesized ZnNPs displayed considerable antimicrobial and antifungal capacity. Similarly, in vitro molecular studies demonstrated the inhibitory activity of ZnNPs against MMP 1. The findings of the present study suggested that biosynthesized ZnNPs that utilize extracts of Eclipta prostrata may be used for therapeutic application in oral diseases and thus is a promising nanomaterial. newline