An Association Between Apo E Gene Polymorphism and Risk of Premature Coronary Heart Disease in Young Smokers

Abstract

Smoking is one of the biggest public health threats worldwide and is regarded as an newlineenvironmental factor which is linked with different genetic and multifactorial disorders. newlineApolipoprotein E (APO-E) gene interacts with environmental factors and the common isoform of newlineAPO-E gene E2, E3, and E4 are the common determinants of plasma lipid concentrations and newlinehave been involved in the pathogenesis of atherosclerosis. The study investigates the gene newlineenvironment interaction of APO-E gene and cigarette smoking and the risk of premature newlinecoronary heart disease (CHD) in young smokers. newlineAim newlineThe aim of the study is to find out the association between APO-E gene polymorphism and risk newlineof premature coronary heart disease in young smokers. newlineMaterials and Methods newlineThis case-control study was conducted on 480 subjects at the Department of Cardiology and newlineMedicine in the age group between 20 to 55 years attending the SRM Medical College Hospital newlineand Research Centre newline